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Siegfried Goldmann

点击:次  更新日期:2014年04月19日  

Siegfried Goldmann

所属学院:轻工化工学院

导师类别:硕士生导师

科研方向:

硕士招生学院:轻工化工学院

个人简述

(300) Siegfried Goldmann,德国国籍,1969-1979年获德国MARBURG大学(德国洪堡大学)博士学位并进行博士后研究工作。1979年进入德国拜耳公司工作,先后从事心血管及代谢疾病的研发工作,后致力于抗病毒、抗细菌先导化合物的高通量筛选,成功发现具有新作用机制的抗HBV病毒的药物。戈尔德曼教授是世界知名抗病毒及抗细菌药专家,拥有数十篇论文、著作及专利。戈尔德曼博士现任东阳光研究院药学部副部长兼任专利部部长。在戈尔德曼博士的言传身教下,药学部100多名研究员受益匪浅,科研水平日益提升。

学科领域科学学位:

专业学位:化学工程

主要论文 1. Carbethoxy-substituted thiazolyldihydropyrimidines

Goldmann, Siegfried; Li, Jing; Liu, Yisong

PCT Int. Appl. (2008), WO 2008154820 A1 20081224.

2. Fluorophenyl-substituted thiazolyldihydropyrimidines

Goldmann, Siegfried; Li, Jing; Liu, Yisong

PCT Int. Appl. (2008), WO2008154818 A1 20081224

3. Discovery of calcium antagonists

Goldmann, Siegfried

Pharmazie in Unserer Zeit (2005), 34(5), 366-373.

4. IKCa-channel blockers. Part 2: Discovery of cyclohexadienes

Urbahns, Klaus; Goldmann, Siegfried; Krueger, Jochen; Horvath, Ervin; Schuhmacher, Joachim; Grosser, Rolf; Hinz, Volker; Mauler, Frank

Bioorganic & Medicinal Chemistry Letters (2005), 15(2), 401-404.

5. Preparation of spirocyclobutyltetrahydroquinolinols as cholesterol ester transfer protein (CETP) inhibitors

Gielen, Heike; Goldmann, Siegfried; Keldenich, Joerg; Paulsen, Holger; Schmeck, Carsten; Siegel, Stephan; Bischoff, Hilmar; Raabe, Martin; Schmidt, Delf; Faeste, Christiane

PCT Int. Appl. (2003), WO2003028727 A1 20030410.

6. Inhibition of Hepatitis B Virus Replication by Drug-Induced Depletion of Nucleocapsids

Deres, Karl; Schroeder, Claus H.; Paessens, Arnold; Goldmann, Siegfried; Hacker, Hans Joerg; Weber, Olaf; Kraemer, Thomas; Niewoehner, Ulrich; Pleiss, Ulrich; Stoltefuss, Juergen; et al

Science (Washington,DC,United States) (2003), 299(5608), 893-896.

7. Method for resolution of the enantiomers of methyl 4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoro-2-pyridinyl)-6-methyl-1,4-dihydro-5-pyrimidinecarboxylate racemate using (-)-camphanic acid

Goldmann, Siegfried; Fey, Peter

PCT Int. Appl. (2002), WO2002094807 A1 20021128.

8. Preparation of pyridinylpyrazoles for the treatment of COPD

Alonso-Alija, Cristina; Goldmann, Siegfried; Dodd, Sara; Fitzgerald, Mary; Nash, Kevin

PCT Int. Appl. (2002), WO2002072571 A2 20020919.

9. Novel non-nucleoside inhibitors of cytomegaloviruses (BAY 38-4766): in vitro and in vivo antiviral activity and mechanism of action

Reefschlaeger, Juergen; Bender, Wolfgang; Hallenberger, Sabine; Weber, Olaf; Eckenberg, Peter; Goldmann, Siegfried; Haerter, Michael; Buerger, Iris;

Trappe, Joerg; Herrington, Janet A.; et al

Journal of Antimicrobial Chemotherapy (2001), 48(6), 757-767.

10. Preparation of 2-heterocyclyl-4-phenyldihydropyrimidines as antiviral agents for treatment of hepatitis B infection

Niewoehner, Ulrich; Stoltefuss, Juergen; Goldmann, Siegfried; Kraemer, Thomas; Schlemmer, Karl-Heinz; Keldenich, Joerg; Paessens, Arnold; Graef, Erwin; Weber, Olaf; Deres, Karl

PCT Int. Appl. (2001), WO2001068647 A1 20010920.

知识产权 Carbethoxy-substituted thiazolyldihydropyrimidines.Goldmann, Siegfried; Li, Jing; Liu, Yisong PCT Int. Appl. (2008), WO2008154820 A1 20081224.

Fluorophenyl-substituted thiazolyldihydropyrimidines.Goldmann, Siegfried; Li, Jing; Liu, Yisong PCT Int. Appl. (2008), WO2008154818 A1 20081224

Preparation of spirocyclobutyltetrahydroquinolinols as cholesterol ester transfer protein (CETP) inhibitors Gielen, Heike; Goldmann, Siegfried; Keldenich, Joerg; Paulsen, Holger; Schmeck, Carsten; Siegel, Stephan; Bischoff, Hilmar; Raabe, Martin; Schmidt, Delf; Faeste, Christiane PCT Int. Appl. (2003), WO2003028727 A1 20030410.

我的团队 2013年拟在广工-东阳光药业研究生联合培养示范基地招收硕士生1名(广工方挂靠赵肃清教授)。

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