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基本信息
姓名:熊凯
性别:男
出生年月:1992-12
政治面貌:中共党员
籍贯:湖南省张家界市
联系方式
电话:(86)15622103946
邮箱:xiongkai@gdut.edu.cn
ORCID:0000-0002-8170-0273
Web of Science Researcher ID:GPW-9975-2022
通讯地址:广州大学城广东工业大学轻工化工学院工学四号馆
教育与工作经历
2023年7月至今 特聘副教授
广东工业大学,轻工化工学院
2021年8月至2023年6月,博士后
中山大学化学学院,材料化学专业,合作导师:梁宏斌教授
2016年08月至2021年6月,博士(直博)
中山大学化学学院,化学生物学专业,导师:计亮年 院士 ;巢晖 教授(国家杰青)
2012年09月至2016年06月,学士
中山大学化学与化工学院,化学生物学专业, 导师:陈禹副教授 (广东省杰青)
研究方向
1. 用于核酸功能调控的金属配合物抗肿瘤新机理研究。
2. 小分子/无机金属纳米材料抗肿瘤试剂诱导细胞死亡通路研究。
3. 功能化有机杂环配体及其金属配合物的设计、合成、结构优化与生物应用
4. 具有催化效应的过渡金属配合物的设计与合成
主持或参与的项目
1. 国家自然科学基金青年项目,核酶为靶的环金属钌(II)配合物诱导细胞免疫原性死亡研究(主持,22207134,30万)2023-01-01至 2025-12-31
2. 中国博士后科学基金面上项目,细胞核靶向新型拓扑异构酶抑制剂克服肿瘤耐药研究(主持,2022M713564,8万)已结题
3. 广东省自然科学基金面上项目,细胞核靶向的新型端粒酶抑制剂克服肿瘤耐药研究(主持, 10万)2023-0101至2025-12-31
4. 国家自然科学基金面上项目,诱导细胞涨亡的铱(III)配合物研究(参与,21778079,64万)已结题
5. 国家自然科学基金青年项目,线粒体内过氧化氢代谢水平检测的多光子激发的近红外荧光探针研究(参与,21701196,25万)已结题
6. 国家自然科学基金青年项目,乏氧响应、多模式抗肿瘤的金属配合物研究(参与,21807119,27.5万)已结题
7. 广东省自然科学基金面上项目,用于乏氧响应增敏治疗的金属配合物抗肿瘤诊疗前药的研究(参与,2020A15150,10万)已结题
8. 国家自然科学基金面上项目,靶向损伤线粒体DNA的铱(III)配合物克服肿瘤耐药研究(参与,21977126,64万)已结题
所在团队
清洁化学技术科研团队(团队负责人:余林教授)
科研成果
迄今为止,在Angew. Chem. Int. Ed.,JACS., Nano Today, Biomaterials, Adv. Healthecare Mater., ACS Appl. Mater. Inter., Chem. Commun.等国际高水平杂志上发表论文18篇,其中第一或共同第一作者8篇。总引用710余次,H-index 14(基于Research Gate)。
发表论文
1. Kai Xiong+, Cheng Ouyang+ (+ equal contributors), Jiaqi Liu, Johannes Karges, Xinlin Lin, Xiang Chen, Yu Chen*, Jian Wan*, Liangnian Ji, and Hui Chao*; Chiral RuII-PtII Complexes Inducing Telomere Dysfunction against Cisplatin-Resistant Cancer Cells, Angewandte Chemie International Edition, 2022, 61: e20220486
2. Kai Xiong, Chen Qian, Yixian Yuan, Lin Wei, Xinxing Liao, Liting He, Thomas W. Rees, Yu Chen*, Jian Wan*, Liangnian Ji, Hui Chao*; Necroptosis Induced by Ruthenium(II) Complexesas Dual Catalytic Inhibitors of Topoisomerase I/II, Angewandte Chemie International Edition, 2020, 59: 16631-16637 (Hot paper)
3. Kai Xiong, Xinlin Lin, Junfeng Kou, Fangmian Wei, Jinchao Shen, Yu Chen,* Liangnian Ji,and Hui Chao*; Apoferritin-Cu(II) Nanoparticles Induce Oncosis in Multidrug-Resistant Colon Cancer Cells, Adv. Healthcare Mater. 2023, 2302564
4. Kai Xiong+, Ying Zhou+ (+ equal contributors), Johannes Karges, Kejie Du, Jinchao Shen, Mingwei Lin, Fangmian Wei, Junfeng Kou, Yu Chen*, Liangnian Ji, Hui Chao*; Autophagy-Dependent Apoptosis Induced by Apoferritin-Cu(II) Nanoparticles in Multidrug-Resistant Colon Cancer Cells., ACS applied materials & interfaces, 2021, 13: 38959-38968
5. Kai Xiong, Fangmian Wei, Yu Chen,* Liangnian Ji and Hui Chao*; Recent Progress in Photodynamic Immunotherapy with Metal-Based Photosensitizers., Small methods, (Accepted)
6. Kai Xiong+ , Ying Zhou+(+ equal contributors), Xinlin Lin, Junfeng Kou, Mingwei Lin, Ruilin Guan, Yu Chen*,Liangnian Ji and Hui Chao*;Cyclometalated Iridium(III) Complexes as Mitochondria-targeting Photosensitizers against Cisplatin-resistant Cells;Photochemistry and Photobiology, 2022, 98: 85–91
7. Kai Xiong, Yu Chen*, Cheng Ouyang, Rui-Lin Guan, Liang-Nian Ji, Hui Chao*;Cyclometalated Iridium(III) Complexes as Mitochondria-targeted Anticancer Agents;Biochimie, 2016, 125: 186-194
8. 熊凯,陈禹*,计亮年,巢晖*, 线粒体靶向铱(III)配合物克服肿瘤耐药, 大学化学, 2022, 37: 2110094
9. Fangmian Wei, Johannes Karges, Jinchao Shen, Lina Xie, Kai Xiong, Xiting Zhang*, Liangnian Ji, Hui Chao*, A Mitochondria-localized Oxygen Self-sufficient Two-photon Nano-photosensitizer for Ferroptosis-boosted Photodynamic Therapy Under Hypoxia, Nano Today, 2022, 44: 101509
10. Shi Kuang, Fangmian Wei, Johannes Karges, Libing Ke, Kai Xiong, Xinxing Liao, Gilles Gasser*, Liangnian Ji, and Hui Chao*, Photodecaging of a Mitochondria-Localized Iridium(III) Endoperoxide Complex for Two-Photon Photoactivated Therapy under Hypoxia, Journal of the American Chemical Society, 2022, 144: 4091−4101
11. Lili Wang, Ruilin Guan, Lina Xie, Xinxing Liao, Kai Xiong, Thomas W. Rees, Yu Chen,Liangnian Ji, and Hui Chao*, An ER-Targeting Iridium(III) Complex That Induces Immunogenic Cell Death in Non-Small-Cell Lung Cancer, Angewandte Chemie International Edition, 2021, 60: 4657-4665 (VIP paper)
12. Jinchao Shen, Johannes Karges, Kai Xiong, Yu Chen, Liangnian Ji, Hui Chao*, Cancer Cell Membrane Camouflaged Iridium Complexes Functionalized Black-titanium Nanoparticles for Hierarchical-targeted Synergistic NIR-II Photothermal and Sonodynamic Therapy, Biomaterials, 2021, 275: 120979
13. Johannes Karges, Kai Xiong, Olivier Blacque, Hui Chao*, Gilles Gasser*, Highly Cytotoxic Copper(II) Terpyridine Complexes as Anticancer Drug Candidates, Inorganica Chimica Acta, 2021, 516 :120137
14. Liting He, Kai Xiong, Lili Wang, Ruilin Guan*, Yu Chen*, Liangnian Ji and Hui Chao*, Iridium(III) Complexes as Mitochondrial Topoisomerase Inhibitors Against Cisplatin-resistant Cancer Cells, Chemical Communications, 2021,57: 8308
15. Shi Kuang, Xinxing Liao, Xianrui Zhang, Thomas W. Rees, Ruilin Guan, Kai Xiong, Yu Chen*, Liangnian Ji, and Hui Chao*, “FerriIridium: A Lysosome-Targeting Iron(III)-Activated Iridium(III) Prodrug for Chemotherapy in Gastric Cancer Cells”, Angewandte Chemie International Edition, 2020, 59: 3315-3321.
16. Jiangping Liu, Xinxing Liao, Kai Xiong, Shi Kuang, Chengzhi Jin, Liangnian Ji and Hui Chao*, Boosting Two-photon Photodynamic Therapy with Mitochondria-targeting Ruthenium–glucose Conjugates, Chemical Communications, 2020, 56: 5839
17. Jia Li, Hongmin Chen, Leli Zeng, Thomas W. Rees, Kai Xiong, Yu Chen*, Liangnian Ji and Hui Chao*, Mitochondria-targeting Cyclometalated Iridium(III) Complexes for Tumor Hypoxic Imaging and Therapy, Inorganic Chemistry Frontiers, 2019, 6: 1003
18. Jia Li, Leli Zeng, Kai Xiong, Thomas W. Rees, Chengzhi Jin, Weijun Wu, Yu Chen,* Liangnian Ji and Hui Chao*, A Biotinylated Ruthenium(II) Photosensitizer for Tumor-targeted Two-photon Photodynamic Therapy, Chemical Communications, 2019, 55: 10972