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陈迁

作者:   来源:      发布日期:2014-05-04   浏览:

陈迁,理学博士,广东工业大学轻工化工学院副教授,硕士生导师。2001年获理学学士学位(中国科学技术大学),2006年获理学博士学位(中科院上海有机化学研究所),2006年11月至2007年11月在法国巴黎国立高等化学学校从事博士后研究,2008年5月至2009年8月在中科院广州生物医药与健康研究院任副研究员,2009年9月至2012年8月在美国东北大学和西弗吉尼亚大学从事博士后研究,2012年12月起在广东工业大学轻工化工学院任教至今。近年来主要从事有机磷/硫功能分子的绿色合成、可见光催化反应和自由基反应等领域的研究,以通讯或第一作者在J. Am. Chem. Soc.、Green Chem.、Org. Lett.、Chem. Commun.、J. Org. Chem.、Adv. Syn. Catal.、Org. Chem. Front.和Organometallics等学术刊物上发表研究论文60余篇,主持国家自然科学基金和广东省科技计划重大项目等项目,出版教材3部,获授权发明专利13件,获市级科学技术三等奖1项。

联系方式:

电子邮箱:qianchen@gdut.edu.cn

通讯地址:广州市番禺区广州大学城外环西路100号广东工业大学轻工化工学院

邮编:510006

研究方向:

有机磷/硫功能分子的绿色合成;可见光催化反应;自由基反应

教育经历:

1996/09–2001/07,中国科学技术大学,化学系,学士

2001/09–2006/07,中科院上海有机化学研究所,博士

工作经历:

2006/11–2007/11,法国巴黎国立高等化学学校,博士后

2008/05–2009/08,中科院广州生物医药与健康研究院,副研究员

2009/09–2010/08,美国西弗吉尼亚大学,化学系,博士后

2010/09–2012/08,美国东北大学,化学与化学生物学系,博士后

2012/12–至今,广东工业大学,轻工化工学院,副教授

代表性论文:

1. Xiaofeng Yu, Nan Huang, Yanping Huo, Xianwei Li, Yan Liu, Keiji Maruoka, Qian Chen* “Photoredox-Mediated Aerobic Oxidative Cleavage of 1,3-Diketones to Access 1,2-Diketones and (Z)-1,4-Enediones” Org. Lett. 2024, 26, 565.

2. Mingjun Liu, Jiarui Zhu, Xuming Jiang, Xiangyun Yang, Qian Chen* “Visible light irradiated photocatalytic C(sp3)–H phosphorylation of xanthenes and 9,10-dihydroacridines with P(O)–H compounds” Org. Biomol. Chem. 2023, 21, 6488.

3. Yuanting Huang, Jinyu Tang, Xi Zhao, Yanping Huo, Yang Gao, Xianwei Li, Qian Chen* “Visible light photocatalytic phosphorylation of heteroatom nucleophiles triggered by phosphorus-centered radical cations” Green Chem. 2023, 25, 4528.

4. Xi Zhao, Xiaofeng Yu, Mingjun Liu, Yanping Huo, Shaomin Ji, Xianwei Li, and Qian Chen* “Direct Benzylic C–H Functionalization with Fluorenones under Visible-Light Irradiation” J. Org. Chem. 2023, 88, 2612.

5. Zafar Mahmood, Jia He, Shuqing Cai, Zhanxiang Yuan, Hui Liang, Qian Chen*, Yanping Huo, Burkhard König, Shaomin Ji* “Tuning the Photocatalytic Performance of Ruthenium (II) Polypyridine Complexes Via Ligand Modification for Visible-Light Induced Phosphorylation of Tertiary Aliphatic Amines” Chem. Eur. J. 2023, 29, e202202677.

6. Bo Liu, Jianji Li, Yifan Hu, Qian Chen*, Yan Liu, Shaomin Ji, Keiji Maruoka, Yanping Huo*, Hao-Li Zhang, “Visible-Light-Induced α-C(sp3)–H Phosphinylation of Unactivated Ethers under Photocatalyst- and Additive-Free Conditions” J. Org. Chem. 2022, 87, 11281.

7. Jianji Li, Bo Liu, Yifan Hu, Xianwei Li, Yanping Huo*, Qian Chen* “Hypervalent iodine-induced disulfenylation of thiophene derivatives with thiophenols” Tetrahedron Lett. 2022, 103, 154041.

8. Yuanting Huang, Yifan Hu, Yukun Han, Yingcong Ou, Yanping Huo, Xianwei Li, Qian Chen* “Direct Synthesis of ortho-Halogenated Arylphosphonates via a Three-Component Reaction Involving Arynes” J. Org. Chem. 2021, 86, 7010.

9. Yuanting Huang, Qian Chen* “Recent Advances in C(sp3)–H Phosphorylation Based on Secondary Phosphine Oxides and Phosphite Esters” Chin. J. Org. Chem. 2021, 41, 4138.

10. Yifan Hu, Yuanting Huang, Xi Zhao, Yang Gao, Xianwei Li, Qian Chen* “A three-component reaction of arynes, sodium sulfinates, and aldehydes toward 2-sulfonyl benzyl alcohol derivatives” Org. Biomol. Chem. 2021, 19, 7066.

11. Xi Zhao, Yingcong Ou, Keiji Maruoka, Yan Liu, Qian Chen* “Recent Progress in the Construction of S—S, P—S and C—S Bonds Involving O2-Initiated Sulfur-Centered Radicals” Chin. J. Org. Chem. 2021, 41, 3366.

12. Cui-Cui Chen, Yi-Qi Zhang, Dong-Xiao Zhong, Xuan-He Huang, Yi-Han Zhang, Wen-Hao Jiang, Ming Li, Qian Chen*, Wing-Leung Wong*, Yu-Jing Lu* “The study of 9,10-dihydroacridine derivatives as a new and effective molecular scaffold for antibacterial agent development” Biochem. Biophys. Res. Commun. 2021, 546, 40.

13. Yingcong Ou, Yuanting Huang, Zhenlin He, Guodian Yu, Yanping Huo, Xianwei Li, Yang Gao, Qian Chen* “A phosphoryl radical-initiated Atherton-Todd-type reaction under open air” Chem. Commun. 2020, 56, 1357.

14. Yingcong Ou, Yuanting Huang, Yu Liu, Yanping Huo, Yang Gao, Xianwei Li, Qian Chen* “Iron-Catalyzed and Air-Mediated C(sp3)–H Phosphorylation of 1,3-Dicarbonyl Compounds Involving C–C Bond Cleavage” Adv. Synth. Catal. 2020, 362, 5783.

15. Yuanting Huang, Qian Chen* “Recent Progress in P- and S-Arylation Reactions of Arynes” Chin. J. Org. Chem. 2020, 40, 4087.

16. Guodian Yu, Yingcong Ou, Danyao Chen, Yuanting Huang, Yan Yan, Qian Chen* “Air-Induced Disulfenylation of Alkenes: Facile Synthesis of Vicinal Dithioethers” Synlett 2020, 31, 83.

17. Qian Chen*, Guodian Yu, Xiaofeng Wang, Yingcong Ou, Yanping Huo “Catalyst-free direct C(sp3)–H sulfenylation of xanthene derivatives using air as the oxidant” Green Chem. 2019, 21, 798.

18. Xiaofeng Wang, Yingcong Ou, Zhenbo Peng, Guodian Yu, Yuanting Huang, Xianwei Li, Yanping Huo, Qian Chen* “TBHP/NH4I‑Mediated Direct N−H Phosphorylation of Imines and Imidates” J. Org. Chem. 2019, 84, 14949.

19. Chunxiao Wen, Guodian Yu, Yingcong Ou, Xiaofeng Wang, Kun Zhang* and Qian Chen* “DDQ-promoted C(sp3)−H phosphorylation of cycloheptatriene” Tetrahedron Lett. 2019, 60, 1345.

20. Qian Chen*, Xiaofeng Wang, Guodian Yu, Chunxiao Wen, Yanping Huo “DDQ-mediated direct C(sp3)–H phosphorylation of xanthene derivatives” Org. Chem. Front. 2018, 5, 2652.

21. Qian Chen*, Chunxiao Wen, Xiaofeng Wang, Guodian Yu, Yingcong Ou, Yanping Huo, Kun Zhang* “DDQ-Promoted Allylic C–H Phosphorylation of 1,3-Diarylpropenes” Adv. Synth. Catal. 2018, 360, 3590.

22. Qian Chen*, Guodian Yu, Xiaofeng Wang, Yulin Huang, Yan Yan, Yanping Huo “Cs2CO3-promoted methylene insertion into disulfide bonds using acetone as a methylene source” Org. Biomol. Chem. 2018, 16, 4086.

23. Qian Chen*, Yulin Huang, Xiaofeng Wang, Jiawei Wu, Guodian Yu “Metal-free NaI/TBHP-mediated sulfonylation of thiols with sulfonyl hydrazides” Org. Biomol. Chem. 2018, 16, 1713.

24. Chunxiao Wen, Jiawei Wu, Yingcong Ou, Yulin Huang, Kun Zhang*, Qian Chen* “TBHP/TBAI-mediated oxidation of thiophenols for the synthesis of tert-butyl arylsulfinates” Tetrahedron Lett. 2018, 59, 3609.

25. Chunxiao Wen, Qian Chen*, Yulin Huang, Xiaofeng Wang, Xinxing Yan, Jiekun Zeng, Yanping Huo, Kun Zhang* “K2CO3-promoted aerobic oxidative cross-coupling of trialkyl phosphites with thiophenols” RSC Adv. 2017, 7, 45416.

26. Qian Chen*, Yulin Huang, Xiaofeng Wang, Chunxiao Wen, Xinxing Yan, Jiekun Zeng “Cs2CO3-promoted carbon−sulfur bond construction via cross-dehydrogenative coupling of thiophenols with acetonitrile” Tetrahedron Lett. 2017, 58, 3928.

27. Qian Chen*, Xiaofeng Wang, Chunxiao Wen, Yulin Huang, Xinxing Yan, Jiekun Zeng “Cs2CO3-promoted cross-dehydrogenative coupling of thiophenols with active methylene compounds” RSC Adv. 2017, 7, 39758.

28. Yulin Huang, Qian Chen* “Fluorination reaction of P(III) compounds with the electrophilic fluorinating reagent Selectfluor” Chin. J. Org. Chem. 2017, 37, 2745.

29. Qian Chen*, Jiekun Zeng, Xinxing Yan, Yulin Huang, Chunxiao Wen, Xingguo Liu, Kun Zhang “Electrophilic Fluorination of Secondary Phosphine Oxides and Its Application to P−O Bond Construction” J. Org. Chem. 2016, 81, 10043.

30. Qian Chen*, Xinxing Yan, Chunxiao Wen, Jiekun Zeng, Yulin Huang, Xingguo Liu, Kun Zhang “Copper-Catalyzed Addition of H−P(O) Bonds to Arynes” J. Org. Chem. 2016, 81, 9476.

31. Qian Chen*, Xinxing Yan, Zhiyun Du, Kun Zhang, Chunxiao Wen “P-Arylation of Dialkyl Phosphites and Secondary Phosphine Oxides with Arynes” J. Org. Chem. 2016, 81, 276.

32. Qian Chen*, Jiekun Zeng, Xinxing Yan, Yulin Huang, Zhiyun Du, Kun Zhang, Chunxiao Wen “Mild and efficient oxidation of phosphorus(III) compounds with Selectfluor” Tetrahedron Lett. 2016, 57, 3379.

33. Chunxiao Wen, Qian Chen*, Zhenwen He, Xinxing Yan, Changyuan Zhang, Zhiyun Du, Kun Zhang* “The insertion of arynes into the O-H bond of aliphatic carboxylic acids” Tetrahedron Lett. 2015, 56, 5470.

34. Wenfeng Liu, Qian Chen*, Jiashen Liang, Zhiyun Du, Kun Zhang, Xi Zheng, George A. O’Doherty “Gold- and Silver-Catalyzed Glycosylation with Pyranone Glycosyl Donors: An Efficient and Diastereoselective Synthesis of α-Anomers” Synlett 2015, 26, 1683.

35. Qian Chen*, Changyuan Zhang, Lili Chen, Chunxiao Wen, Zhiyun Du*, Huixiong Chen, Kun Zhang “α-Monoarylation and tandem arylation-insertion of malonates with arynes” Tetrahedron Lett. 2015, 56, 2094.

36. Lili Chen, Changyuan Zhang, Chunxiao Wen, Kun Zhang*, Wenfeng Liu, Qian Chen* “Gold-catalyzed cyclotrimerization of arynes for the synthesis of triphenylenes” Catal. Commun. 2015, 65, 81.

37. Qian Chen*, Changyuan Zhang, Chunxiao Wen, Jin Fang, Zhiyun Du*, Dongling Wu “Platinum- and gold-catalyzed hydroalkoxylation and tetramerization of propiolate esters” Catal. Commun. 2014, 56, 101.

38. Qian Chen, Jun Ou, Guo-Shu Chen, Tian-Hui Liu, Bin Xie, Hai-Bo Liang, Li-Qiong Xie, Yi-Xin Chen* “Asymmetric addition of triethylaluminium to aromatic aldehydes catalyzed by titanium-(5,5’-biquinoline-6,6’-diol) complexes” Chirality 2014, 26, 268.

39. Qian Chen, Yashan Zhong, George A. O’Doherty* “Convergent De Novo Synthesis of Vineomycinone B2 Methyl Ester” Chem. Commun. 2013, 49, 6806.

40. Ravula S. Babu,† Qian Chen,† Sang-Woo Kang,† Maoquan Zhou†, George A. O’Doherty* De Novo Asymmetric Synthesis of All-D-, All-L-, and D-/L-oligosaccharides Using Atom-less Protecting Groups” J. Am. Chem. Soc. 2012, 134, 11952. (†contributed equally)

41. Alexandre Pradal,† Qian Chen,† Pierre F. dit Bel, Patrick Y. Toullec*, Véronique Michelet* “Gold-Catalyzed Cycloisomerization of Functionalized 1,5-Enynes – An Entry to Polycyclic Framework” Synlett 2012, 23, 74. (†contributed equally)

42. Qian Chen, Michael Mulzer, Pei Shi, Penny J. Beuning,* Geoffrey W. Coates*, George A. O’Doherty* “De Novo Asymmetric Synthesis of Fridamycin E” Org. Lett. 2011, 13, 6592.

43. Liu Ye, Qian Chen*, Jiancun Zhang*, Veronique Michelet* “PtCl2-Catalyzed Cycloisomerization of 1,6-Enynes for the Synthesis of Substituted Bicyclo[3.1.0]hexanes” J. Org. Chem. 2009, 74, 9550.

科研项目:

1. 国家自然科学基金:“新型碳糖苷化方法及其在抗生素Fridamycin A,B,D合成中的应用”,项目编号:21242002。(主持

2. 广东省科技计划重大项目(国际科技合作领域):“新型含磷有机光电材料的三组分反应高效合成及性能研究”,项目编号:2021A0505030069。(主持

3. 广东省科技计划项目:“基于芳基膦氧化物的有机小分子发光材料的设计合成及性能研究”,项目编号:2017A010103044。(主持

4. 广东省科技计划项目:“海洋微生物活性代谢产物fridamycin E的碳糖苷衍生物的合成及其生物活性与构效关系研究”,项目编号:2015A020211026。(主持

5. 广东省功能分子工程重点实验室开放基金:“芳基膦氧化物发光材料的设计合成研究”,项目编号:2016kf07。(主持

6. 广东工业大学“青年百人计划”项目:“烯炔异构化反应及其在天然产物合成中的应用”,项目编号:220413506。(主持

7. 低温糖苷类潜香物研制技术开发及表征服务合同(云南中烟工业有限责任公司技术中心),项目编号:2020539200340176。(主持

8. 拉莫三嗪技术服务项目(三金集团湖南三金制药有限责任公司):“拉莫三嗪工艺改进、分子结构设计”。(主持

教材:

1. 《大学通用化学实验技术》上册,高等教育出版社,2009副主编

2. 《大学通用化学实验技术》下册,高等教育出版社,2010副主编

3. 《大学通用化学实验技术学习指南》,科学出版社,2014副主编

代表性授权专利:

1. 区颖聪,陈迁,霍延平,王肖峰. 一种9H-氧/硫杂蒽化合物的合成方法. 授权日:2023.02.03,专利号:ZL201910403546.4

2. 刘波,霍延平,陈迁,赵经纬. 一种苄基氧化膦类化合物及其制备方法和应用. 授权日:2022.04.19,专利号:ZL202110683487.8

3. 温春晓,张焜,陈迁,霍延平,杜志云. 一种芳基氧化膦类化合物及其合成方法和应用. 授权日:2021.12.10,专利号:ZL201811074886.9

4. 温春晓,陈迁,王肖峰,余国典,霍延平,张焜. 一种烯丙基氧化膦类化合物的合成方法. 授权日:2020.09.22,专利号:ZL201810671523.7

5. 陈迁,黄昱霖,吴佳微,霍延平,王肖峰,余国典,温春晓. 一种硫代磺酸酯类化合物的合成方法. 授权日:2019.11.08,专利号:ZL201810045052.9

6. 陈迁,王肖峰,温春晓,晏鑫星,曾洁坤,黄昱霖,霍延平,杜志云,张焜. 一种α-亚磺酰化羰基化合物及其合成方法和应用. 授权日:2019.08.02,专利号:ZL201710441531.8

7. 陈迁,黄昱霖,温春晓,晏鑫星,曾洁坤,王肖峰,霍延平,杜志云,张焜. 一种酮类化合物及其合成方法. 授权日:2021.01.05,专利号:ZL201710150467.8

8. 陈迁,晏鑫星,温春晓,曾洁坤,黄昱霖,杜志云,张焜. 一种高选择性合成碘苯类化合物的方法. 授权日:2018.12.14,专利号:ZL201610100344.9

学术报告

1. 2016年11月18-20日,福州大学,中国化学会第十四届全国氟化学会议 (邀请报告)

2. 2016年11月26-29日,广东工业大学,第一届国际有机化学会议(口头报告)

3. 2018年10月7-10日,广西师范大学,第八届岭南有机化学论坛(邀请报告)

4. 2018年10月24-27日,宁波工程学院,“催化助力化学新时代”学术论坛(邀请报告)

5. 2021年11月19-22日,暨南大学,第十届岭南有机化学论坛(邀请报告)

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