张华堂副教授

Huatang Zhang Associate Professor

所属学院：轻工化工学院

导师类别：硕士生导师

科研方向：

1.小分子有机荧光探针

2.药物可控释放及荧光检测

联系方式：

电话：18244998144邮箱：htzhang@gdut.edu.cn

硕士招生学院：轻工化工学院

个人简述

张华堂，男，博士，副教授，硕士生导师，广东省珠江高层次人才计划-青年拔尖人才。主要围绕小分子有机荧光探针的设计及其生物识别应用展开研究。在Chemical Science, Biomaterial, Biosensors and Bioelectronics, Chemical Communication等重要期刊发表SCI论文二十多篇，H-index为17。主持承担国家自然科学基金项目1项，广东省自然科学基金1项，广东工业大学青年百人1项。

学科领域

科学学位：化学工程与技术应用化学应用化学

专业学位：化学工程

教育背景

2016.3—至今广东工业大学轻工化工学院副教授

2015.9—2016.8香港城市大学生物与化学系博士后导师：孙红燕教授

2012.6—2015.8香港城市大学生物与化学系博士导师：孙红燕教授

2006.9—2009.7南开大学理学硕士导师：宋礼成院士、胡青眉教授

2002.9—2006.7陕西师范大学应用化学理学学士导师：魏俊发教授、石先莹教授

主要荣誉

广东省珠江高层次人才计划-青年拔尖人才

广东工业大学“青年百人计划”A类引进人才

香港城市大学研究生杰出学术表现奖

广东工业大学先进科技工作者

广东工业大学轻工化工学院教书育人奖

代表性论文

1.G. Zheng, Z. Li, Q. Duan, K. Cheng, Y. He, S. Huang,H. Zhang,*Y. Jiang,* Y. Jia, H. Sun,* Two quenching groups are better than one: A robust strategy for constructing HOCl fluorescent probe with minimized background fluorescence and ultra-high sensitivity and its application of HOCl imaging in living cells and tissues，Sens. Actuators B Chem.,2020, 310, 127890.

2.Z. Li, S. Huang, Y. He, Q. Duan, G. Zheng, Y. Jiang, L. Cai, Y. Jia,H. Zhang,*D. Ho*, AND logic gate based fluorescence probe for simultaneous detection of peroxynitrite and hypochlorous acid, Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy,2020, 230, 118073.

3.K.-F. Chen, S. Liu, M. Gao, J. Wang, Y. Wang, X. Chen, Y. Chen, L. Ren,H. Zhang, Y.-G. Jia,* X. X. Zhu*, AIE-active and thermoresponsive alternating polyurethanes of bile acid and PEG for cell imaging,ACS Appl. Polym. Mater.,2019, 1, 2973-2980.

4.Q. Duan,^‡G. Zheng,^‡Z. Li,^‡K. Cheng, J. Zhang, L. Yang, Y. Jiang,H. Zhang,*J. He,*and H. Sun*, An ultra-sensitive ratiometric fluorescent probe for hypochlorous acid detection by the synergistic effect of AIE and TBET and its application of detecting exogenous/endogenous HOCl in living cells,J. Mater. Chem. B,2019, 7, 5125-5131.

Note:2019 Journal of Materials Chemistry B Most Popular Articles

5.Y. Jiang,^‡Q. Duan,^‡G. Zheng,^‡L. Yang, J. Zhang, Y. Wang,H. Zhang,*J. He, H. Sun* and D. Ho*, An ultra-sensitive and ratiometric fluorescent probe based on the DTBET process for Hg²⁺detection and imaging applications, Analyst,2019, 144, 1353-1360.

6.Y. Jiang,^‡G. Zheng,^‡Q. Duan,^‡L. Yang, J. Zhang,H. Zhang,*J. He,*H. Sun and D. Ho*, Ultra-sensitive fluorescent probes for hypochlorite acid detection and exogenous/endogenous imaging of living cells,Chem. Commun.,2018, 54, 7967-7970

7.Y. Jiang,^‡G. Zheng,^‡N. Cai,^‡H. Zhang,*Y. Tan, M. Huang, Y. He, J. He,* and H. Sun*, A fast-response fluorescent probe for hypochlorite acid detection and its application of exogenous and endogenous HOCl imaging in living cells,Chem. Commun.,2017, 53, 12349 - 12352

8.T. Kong,^‡G. Guo,^‡H. Zhang,^‡L. Gao,* Post-synthetic modification of polyvinyl alcohol with a series of N-alkyl-substituted carbamates towards thermo and CO₂-responsive polymers,Polym. Chem.,2017,8, 5769–5779.

9.H. Zhang, P. Xiao, Y. T. Wong, W. Shen, M. Chhabra, R. Peltier, Y. Jiang, Y. He, J. He, Y. Tan, Y. Xie, D. Ho, Y.-W. Lam,* J. Sun,* H. Sun,* Construction of an alkaline phosphatase-specific two-photon probe and its imaging application in living cells and tissues,Biomaterials,2017, 140, 220–229

10.H. Zhang,^‡L. Feng,^‡Y. Jiang, Y.-T. Wong, Y. He, G. Zheng, J. He, Y. Tan, H. Sun,* and D. Ho*, A reaction-based near-infrared fluorescent sensor for Cu²⁺detection in aqueous buffer and its application in living cells and tissues imaging,Biosensors and Bioelectronics,2017,94, 24.

11.Z. Xie, J. Ge,H. Zhang, T. Bai, S. He, J. Ling, H. Sun,* Q. Zhu,* A highly selective two-photon fluorogenic probe for formaldehyde and its bioimaging application in cells and zebrafish,Sensors and Actuators B: Chemical,2017,241, 1050

12.Y. Tan, L. Zhang, K. H. Man, R. Peltier, G. Chen,H. Zhang, L. Zhou, F. Wang, D. Ho, S. Q. Yao, Y. Hu,*and H. Sun,*Reaction-based off-on near-infrared fluorescent probe for imaging alkaline phosphatase activity in living cells and mice,ACS Appl. Mater. Inter.,2017,9, 6796.

13.H. Zhang, R. Liu, L. Li, P. Wang, S. Q. Yao, Z. Xu, H. Sun,*A minimalist fluorescent probe for differentiating Cys, Hcy and GSH,Chem. Sci.,2016,7, 256.

Note: Top 50 Articles of 2016: Analytical, Biological and Medicinal Chemistry.

高被引论文（2016年-至今）

14.Y. Xie, J. Ge, H. Lei, B. Peng,H. Zhang, D. Wang, S. Pan, G. Chen, L. Chen, Y. Wang, Q. Hao, S. Q. Yao, and H. Sun,* Fluorescent probes for single-Step detection and proteomic profiling of histone deacetylases,J. Am. Chem. Soc.,2016,138, 15596.

15.H. Lu,H. Zhang, J. Chen, J. Zhang, R. Liu, H. Sun, Y. Zhao, Z. Chai, Y. Hu,*A thiol Fluorescent probe reveals the intricate modulation of cysteine’s reactivity by Cu(II),Talanta,2016,146, 477.

16.H. Zhang, R. Liu, Y. Tan, W. H. Xie, H. Cheung, H. Sun,*A FRET-based ratiometric fluorescent probe for nitroxyl detection in living cells,ACS Appl. Mater. Inter.,2015,11, 5438.

17.H. Zhang, C. Zhang, R. Liu, L. Yi, H. Sun,*A highly selective and sensitive fluorescent thiol probe through dual-reactive and dual-quenching groups,Chem. Commun.,2015,51, 2029.

18.H. Zhang, Y. Xie, P. Wang, G. Chen, R. Liu, Y. Lam, Y. Hu, Q. Zhu, H. Sun,*An iminocoumarin benzothiazole-based fluorescent probe for imaging hydrogen sulfide in living cells,Talanta,2015,135, 149.

Note:Most downloaded articles in 2015

19.Y. Tan, R. Liu,H. Zhang, R. Pelitier, Y. W. Lam, Q. Zhu, Y. Hu, H. Sun,*Design and synthesis of near-infrared fluorescent probes for imaging of biological nitroxyl,Sci. Rep.,2015, 10.1038/srep16979.

20.G. Chen, Y. Xie,H. Zhang, P. Wang, H. Cheung, M. Yang, H. Sun,*A general colorimetric method for detecting protease activity based on peptide-induced gold nanoparticle aggregation,RSC Adv.,2014,4, 6560.

21.P. Wang, Z. Na, J. Fu, C. Tan,H. Zhang, S. Q. Yao, H. Sun, Microarray immobilization of biomolecules using a fast trans-cyclooctene (TCO)-tetrazine reaction,Chem. Commun.,2014,50, 11818.

22.X. Li,H. Zhang, Y. Xie, Y. Hu, H. Sun, Q. Zhu,*Fluorescent probes for detecting monoamine oxidase activity and cell imaging,Org. Biomol. Chem.,2014,12, 2033.

23.H. Zhang, P. Wang, G. Chen, H. Cheung, H. Sun,*A highly sensitive fluorescent probe for imaging hydrogen sulfide in living cells,Tetrahedron Lett.,2013,54, 4826.

24.H. Zhang,P. Wang, Y. Yang, H. Sun,*A selective fluorescent probe for thiols based on α,β-unsaturated acyl sulfonamide,Chem. Commun.,2012,48, 10672.

25.Y. Jiang,H. Zhang, Q. He, Z. Hu, X. Chang,*Selective solid-phase extraction of trace mercury(II) using a silica gel modified with diethylenetriamine and thiourea,Microchim. Acta,2012,178, 421.