刘艳Yan Liu博士教授

导师类型：博士生/硕士生导师

所属学院：轻工化工学院

职务：基础教学系主任、广东省植物资源生物炼制重点实验室副主任

研究方向：

1、 有机合成方法学：不对称催化、自由基化学；

2、 药物化学：基于靶点的药物设计合成、药效评价和作用机理研究；

3、 神经退行性疾病相关药物研究与开发

科研团队：

与法国科学院Bernard Meunier院士和日本京都大学Keiji Maruoka教授，合作建立了国际化团队：新药开发及手性催化团队。团队成员现有教师7人。其中，教授5人，青百副教授2人。团队现有博士后、在读博士和硕士研究生20余人。团队因国际合作获“中国政府友谊奖”（中国政府颁发给外国人的最高奖项）;广东省科技合作奖2项。

团队主页：https://www.pharm.kyoto-u.ac.jp/orgcat/ch/index.html

联系方式：yanliu@gdut.edu.cn

个人介绍：

刘艳，女，博士，教授，博士生导师。基础教学系主任、广东省植物资源生物炼制重点实验室副主任。2007年毕业于中山大学，获博士学位。2007年7月至2009年底，香港浸会大学，中医药学院，博士后，导师：姜志宏教授，主要从事中药化学、中药香港标准等方面的工作。2010年至2013年2月，日本京都大学，博士后，导师：Keiji Maruoka教授，主要从事手性药物设计合成、有机合成方法学、不对称催化研究。2013年、2016年，法国科学院配位化学研究所，访问学者，合作者：Bernard Meunier院士，主要从事抗阿尔茨海默病药物开发工作。2013年回国，以青年“百人计划”加入广东工业大学。

已发表学术论文50余篇，获得中国授权发明专利15项，获国际授权专利4项，PCT专利1项。获国家自然科学基金资助2项、留学归国人员启动基金1项、广东省重点领域研发计划1项、广东工业大学“青年百人计划启动基金”资助。2020年，获广东省科技进步二等奖。

工作经历

2013.01﹣至今，广东工业大学“青年百人计划”，教授，博士生导师

2013/2016，法国CNRS-LCC，访问学者

2010.01–2013.02，日本京都大学，博士后

2007.07–2009.12，香港浸会大学，博士后

教育背景：

2004.09–2007.07，中山大学，理学博士

2002.09–2004.07，中山大学，理学硕士

科研项目

1、国家自然科学基金面上项目：基于铜离子特异性调控的AD记忆损伤恢复及作用机制研究，2020-2023，主持

2、广东省重点领域研发计划：新型手性药物绿色合成催化技术的研发与产业化应用，2019-2021，主持（广东工业大学部分）

3、国家自然科学基金青年项目：铜离子调控策略抑制AD氧化应激：新型选择性螯合剂的设计合成与活性研究，2016-2018，主持

4、广东省新药筛选重点实验室开放课题：基于逆转AD记忆损伤的先导化合物的优化及活性研究，2018-2020，主持

5、留学回国人员科研启动基：铜离子螯合剂的设计合成及抑制A-beta聚集的活性研究，2015-2017，主持

6、广东工业大学“青年百人”科研启动基金，2013-2018，主持

讲授课程：

研究生课程：《高等有机化学》

本科生课程：《有机化学》；《有机化学实验》；《Organic Chemistry》

代表性学术论文：

1 Hanbin Lu, Canhua Zhou, Zhe Wang, Terumasa Kato*, Yan Liu*, Keiji Maruoka* Fe-Catalyzed Three-Component Coupling Reaction of α,β,γ,δ-Unsaturated Carbonyl Compounds and Conjugate Dienes with Alkylsilyl Peroxides and Nucleophiles. J. Org. Chem.2022,87, 13, 8824–8834.

2 Jiaqi Su, Siwei Shu , Yinwu Li , Yong Chen , Jinxiang Dong , Yan Liu*, Yanxiong Fang*, Zhuofeng Ke*. Mechanism-Dependent Selectivity: Fluorocyclization of Unsaturated Carboxylic Acids or Alcohols by Hypervalent Iodine.Frontiers in Chemistry, 2022, 10,897828.

3 Huatai Liang, Zhurong Lia, Yan Liu,* Sei Murayamac, Hiroshi Naka,* Keiji Maruoka.* Synthesis of optically pure, deuterated Maruoka Catalysts and their chemical reactivity. Tetrahedron Letters 2022, 96, 153753.

4 Youzhi Li, Michel Nguyen, Laure Vendier, Anne Robert∗, Yan Liu∗, Bernard Meunier.X-Ray diffraction structure of Cu(II) and Zn(II) complexes of 8-aminoquinoline derivatives (TDMQ), related to the activity of these chelators as potential drugs against Alzheimer’s disease Journal Molecular Structure., 2022, 1251, 132078.

5 Youzhi Li, Xuemei Chen, Daya Huang, Zhenming Xie, Yan Liu.Hypervalent Iodine-Mediated Chemoselective Bromination of Terminal Alkynes. Frontiers in Chemistry, 2022, 10, 879789.

6 Youzhi Li, Anthony Loureiro, Michel Nguyen, Marion Laurent, Christian Bijani, FrançoiseBenoit-Vical, Anne Robert,* Yan Liu,* Bernard Meunier.* ChemistryOpen, 2022. 11(5), e202200064.

7 Weiping Xu, Terumasa Kato*, Yan Liu*,Keiji Maruoka*, Fe-Catalyzed Dicarbofunctionalization of Vinylarenes with Alkylsilyl Peroxides and β‑Keto Carbonyl Substrates. Organic Letter, 2022, 24, 14, 2641–2645

8 Wenfeng Zeng, Weiping Xu, Qin Yang, Terumasa Kato, * Yan Liu, * and Keiji Maruoka*. A new approach for the copper-catalyzed functionalization of alkyl hydroperoxides with organosilicon compounds via in-situ-generated alkylsilyl peroxides. Tetrahedron, 2022，112，132627.

9 Canhua Zhou, Jiamin Lv, Weiping Xu, Hanbin Lu, Terumasa Kato,* Yan Liu,* Keiji Maruoka,* Highly Selective Monoalkylation of Active Methylene and Related Derivatives using Alkylsilyl Peroxides by a Catalytic CuI-DMAP System. AsianJ. Org. Chem.2021,10, 2625–2631

10 Yaru Jing, Jiahao Liu, Zongren Ye, Jiaqi Su,Yan Liu * and Zhuofeng Ke *, The Cooperative Role of Innocent Ligand in N-heterocyclicnCarbene Manganese Catalyzed Carbon Dioxide Hydrogenation,Catal. Sci. Technol., 2021,11, 7189-7199.

11 Weiping Xu, Yan Liu, Terumasa Kato,* Keiji Maruoka* The Formation of C−C or C−N Bonds via the Copper-Catalyzed Coupling of Alkylsilyl Peroxides and Organosilicon Compounds: A Route to Perfluoroalkylation.Org. Lett.2021,23, 1809−1813.

12 Weiping Xu, Wenfeng Zhong, Qin Yang, Terumasa Kato,* Yan Liu,* and Keiji Maruoka*. In-situ-generation of alkylsilyl peroxides from alkyl hydroperoxides and their subsequent copper-catalyzed functionalization with organosilicon compounds.Tetrahedron Letters.2021,75, 153144.

13 Hanbin Lu, Jiamin Lv, Canhua Zhou, Mi Zhou, Yanxiong Fang, Jinxiang Dong, Terumasa Kato,* Yan Liu,* Keiji Maruoka.Remarkable Effect of tert-Amine Additives in the Asymmetric Direct Michael Reaction of Ketones with β-Arylnitroethenes Catalyzed by an L-Hydroxyproline-Based Amino Tf-Amide Organocatalyst Eur. J. Org. Chem. 2021, 1909–1912.

14 Jiamin Lv, Weiping Xu, Hanbin Lu, Terumasa Kato,* Yan Liu,* Keiji Maruoka.The copper-catalyzed selective monoalkylation of active methylene compounds with alkylsilyl peroxides. Org. Biomol. Chem., 202119,2658−2662.

15 Jie Zhao; Qihui Shi; Hongda Tian; Youzhi Li; Yan Liu; Zhen Xu; Anne Robert*; Qiong Liu*; Bernard Meunie* “TDMQ20, a Specific Copper Chelator, Reduces Memory Impairments in Alzheimer’s Disease Mouse Models” ACS Chem. Neurosci, 2020,12, 140-149.

16 Cuilian, Ke; Weiping, Xu; Da, Liu; Yan, Liu*; Keiji, Maruoka* Chiral Resolution of Biphenol and Asymmetric Alkylation under Phase Transfer Catalysis.Chinese Journal of Organic Chemistry, 2020, 40(7), 1955-1966

17 Tan, Jiashen; Zhu, Weiqin; Xu, Weiping; Jing, Yaru; Ke, Zhuofeng; Liu, Yan*; Maruoka, Keiji* Hypervalent Iodine-Mediated Diastereoselective alpha-Acetoxylation of Cyclic Ketones.Frontiers in Chemistry, 2020, 8, 467

18 Yaru, Jing; Zongren, Ye; Jiaqi, Su; Yishun, Feng; Ling-Bo, Qu; Yan, Liu*; Zhuofeng, Ke*.The potential of d6 non-noble metal NHC catalysts for carbon dioxide hydrogenation: group and row effects. Catalysis Science & Technology, 2020, 10(16), 5443-5447

19 Lan, Xiao-Bing; Ye, Zongren; Liu, Jiahao; Huang, Ming; Shao, Youxiang; Cai, Xiang; Liu, Yan*; Ke, Zhuofeng* Sustainable and Selective Alkylation of Deactivated Secondary Alcohols to Ketones by Non-bifunctional Pincer N-heterocyclic Carbene Manganese.Chemsuschem, 2020, 13(10),2557-2563

20 Hanbin Lu, Jiamin Lv, Cuihua Zhou, Terumasa Kato, Yan Liu, Keiji Maruoka,Practical Synthesis of High-Performance Amino Tf-Amide Organocatalysts for Asymmetric Aldol Reactions.Asian J. Org. Chem. 2020, 9, 206 –209.

21 Lan, X.-B.; Ye, Z.-R.; Huang, M.; Liu, J.H.; Liu, Yan*; Ke, Z.F.* Nonbifunctional Outer-Sphere Strategy Achieved Highly Active α-Alkylation of Ketones with Alcohols by N-Heterocyclic Carbene Manganese (NHC-Mn). Org. Lett., 2019, 21(19), 8065–8070

22 Jiang, J.X.; Liu, H.H.; Cao, L.L.; Zhao, C.Y.; Liu, Yan;* Ackermann, L.;* Ke, Z.F.* Metallalkenyl, Metallacyclopropene, or Metallallylcarbenoid? Ru-Catalyzed Annulation between Benzoic Acid and Alkyne. ACS Catal., 2019, 9, 9387−9392

23 Li, Youzhi; Nguyen, Michel; Baudoin, Morgane; Vendier, Laure; Liu, Yan*; Robert, Anne*; Meunier, Bernard*Why Is Tetradentate Coordination Essential for Potential Copper Homeostasis Regulators in Alzheimer's Disease? European Journal of Inorganic Chemistry, 2019, xx (xx): 4172-4178

24 Y. Liu, M. Nguyen, A. Robert, B. Meunier. Metal Ions in Alzheimer’s Disease: A Key Role or Not? Acc. Chem. Res,2019,52(7),2026-2035.

25 Huang, Ju; Nguyen, Michel; Liu, Yan; Robert, Anne; Meunier, Bernard. Synthesis and characterization of 8-aminoquinolines, substituted by electron-donating groups, as high affinity copper chelators for the treatment of Alzheimer’s disease.C. R. Chimie. 2019,22,419-427

26 Huang, Ming; Li, Yinwu; Liu, Jiahao; Lan, Xiao-Bing; Liu, Yan; Zhao, Cunyuan; Ke, Zhuofeng*. Bifunctional Strategy to N-Heterocyclic Carbene Stabilized Iridium Complex Catalyzed N-Alkylation of Amines with Alcohols in Aqueous.Green Chem.,2019, 21, 219-224.

27 Siwei Shu, Meijie Huang, Jingxing Jiang, Ling-Bo Qu, Yan Liu * and Zhuofeng Ke.Catalyzed or non-catalyzed: chemoselectivity of Ru-catalyzed acceptorless dehydrogenative coupling of alcohols and amines via metal–ligand bond cooperation and (de)aromatization. Catal. Sci. Technol.,2019,9, 2305–2314

28 Huang, Ju;Michel Nguyen, Yan Liu,* Anne Robert,* Bernard Meunier.The TDMQ Regulators of Copper Homeostasis Do Not Disturb the Activities of Cu,Zn-SOD, Tyrosinase, or the CoIII Cofactor Vitamin B12.Eur. J. Inorg. Chem.2019,2019(10),1384–1388

29 Shu, Siwei; Li, Yinwu; Jiang, Jingxing; Ke, Zhuofeng*, Liu, Yan*. Mechanism of Hypervalent Iodine Promoted Fluorocyclization of Unsaturated Alcohols: Metathesis via Double Acids Activation.J. Org. Chem.,2019, 84 (1), 458–462.

30 Shu, Siwei; Liu, Zhao; Li, Yukui; Ke, Zhuofeng*,Liu, Yan*. Diastereoselectivity in a cyclic secondary amine catalyzed asymmetric Mannich reaction: a model rationalization from DFT studies.Org. Chem. Front.,2018, 5, 2148-2157.

31 Zhang Jianyu; Shao Youxiang; Li Yinwu; Liu Yan*; Ke Zhuofeng*. Rational design of FLP catalysts for reversible H2 activation: A DFT study of the geometric and electronic effects.Chin. Chem. Lett. 2018, 29, 1226-1232.

32 Li, Youzhi; Huang, Daya; Huang, Ju; Liu, Yan*; Maruoka, Keiji*. Chemoselective Preparation of 1-Iodoalkynes, 1,2-Diiodoalkenes, and 1,1,2-Triiodoalkenes Based on the Oxidative Iodination of Terminal Alkynes.J. Vis. Exp. 2018, (139), e58063, doi:10.3791/58063 (2018)

33 Daya Huang,Youzhi Li,Yan Liu*, Bernard Meunier*. Synthesis and Chelation selectivity Evaluation of 8-Aminoquinoline Derivatives as Copper Chelator, Chin. J. Org. Chem. 2019, 38,500～506

34 Zhang, Weixin;Liu, Yan*; Hureau, Christelle; Robert, Anne*; Meunier, Bernard. N₄-Tetradentate Chelators Efficiently Regulate Copper Homeostasis and Prevent ROS Production Induced by Copper-Amyloid-β_1–16.Chem. Eur. J.2018, 24, 7825-7829.

35 Zhang, Weixin; Huang, Daya; Huang, Meijie; Huang, Ju; Wang, Dean; Liu, Xingguo; Nguyen, Michel; Vendier, Laure; Mazères, Serge; Robert, Anne*; Liu, Yan*; Meunier, Bernard*. Preparation of new tetradentate copper chelators as potential anti-Alzheimer agents,ChemMedChem, 2018, 13, 684 -704.

36 Zhang, Weixin; Huang, Meijie; Bijani, Christian;Liu, Yan*; Robert, Anne*; Meunier, Bernard. Synthesis and characterization of copper-specific tetradendate ligands as potential treatment for Alzheimer's disease. Comptes Rendus Chimie (C. R. Chimie), 2018, 21, 475-483.

37 Shao, Youxiang; Zhang, Jianyu; Li, Yinwu; Liu Yan*; Ke, Zhuofeng*. Frustrated Lewis Pair Catalyzed C−H Activation of Heteroarenes: A Stepwise Carbene Mechanism Due to Distance Effect.Org. Lett.,2018, 20(4), 1102−1105.

38 Nguyen, Michel; Huang, Meijie;Liu, Yan; Meunier, Bernard; Robert, Anne*. Is iron associated with amyloid involved in the oxidative stress of Alzheimer's disease. Comptes Rendus Chimie (C. R. Chimie) 2017, 20(11~12), 987-989

39 Lee, Hyo-Jun; Moteki, Shin A.; Arumugam, Natarajan; Almansour, Abdulrahman I.; Kumar, Raju Suresh;Liu,Yan;Keiji Maruoka* Practical Synthesis of Two Different Pseudoenantiomeric Organocatalysts with cis-Cyclohexanediamine Structure from a Common Chiral Source.Asian J. Org. Chem. 2017, 6, 1226–1230.

40 Li, Yinwu;, Zhang, Jianyu; Shu, Siwei; Shao Youxiang;Liu, Yan*, Ke, Zhuofeng,* Boron-Based Lewis Acid Transition Metal Complexes as Potential Bifunctional Catalysts.Chin. J. Org. Chem. 2017, 37, 2187-2202.

41 Liu, Yan;* Huang, Daya; Huang, Ju; Maruoka, Keiji.*Hypervalent Iodine Mediated Chemoselective Iodination of Alkynes.J. Org. Chem.2017, 88(22), 11865-11871.

42 Dao, Pascal; Ye, Feifei;Liu,Yan;Du, Zhi Yun; Zhang, Kun; Dong, Chang Zhi; Meunier, Bernard; Chen, Huixiong.* Development of Phenothiazine-Based Theranostic Compounds That Act Both as Inhibitors of β-Amyloid Aggregation and as Imaging Probes for Amyloid Plaques in Alzheimer’s Disease.ACS Chem. Neurosci. 2017, 8, 798−806

43 Liu, Yan;* Arumugam, Natarajan; Almansour, Abdulrahman I.; Kumar, Raju Suresh; Maruoka, Keiji.* Synthesis of Both Enantiomeric Amino Acid, Mannich, and Aldol Derivatives by Asymmetric Organocatalysis.Chemical Record.,2017, 17(10), 1059-1069.

44 Chen, Cheng-Yu; Bai, Li-Ping; Ke, Zhuo-Feng;Liu, Yan;Wang, Jing-Rong;* Jiang, Zhi-Hong.* G-Quadruplex DNA-binding quaternary alkaloids from Tylophora atrofolliculata.RSC Adv.,2016, 6, 114135–114142

45 Jiang, Jingxing;Liu, Yan; Hou, Cheng; Li, Yinwu; Luan, Zihong; Zhao Cunyuan; and Ke, Zhuofeng*. Rationalization of the Selectivity between 1,3- and 1,2-Migration: DFT Study on Gold(I)-Catalyzed Propargylic Ester Rearrangement.Org. Biomol. Chem.,2016, 14, 3558–3563.

46 Li, Gai-Li; Cai, Chao-Yun; He, Jia-Yun; Rao, Li; Ma, Lin;Liu, Yan*; Wang, Bo.* Synthesis of 3- acyloxyxanthone derivatives as α-glucosidase inhibitors: a further insight into the 3-substituents’ effect.Bioorg. Med. Chem.2016, 24(7), 1431-1438.

47 Robert, A.;Liu, Yan; Nguyen M.; Meunie B.* Regulation of Copper and Iron Homeostasis by Metal Chelators: APossible Chemotherapy for Alzheimer’s Disease.Acc. Chem. Res.,2015, 48 (5), 1332–1339.