讲座嘉宾：George O’Doherty 教授（美国东北大学）

讲座主持：霍延平 教授

讲座时间：2019年6月21日（周五）上午10:00

讲座地点：工四-202

嘉宾简介：

Prof. Dr.George O’Doherty is a Professor of Chemistry and Chemical Biology at Northeastern University in Boston MA.He was born in Kilkenny, Ireland, the son of two Ph.D. organic chemists, who at a young age brought him to the United States to continue in the family business.Hisresearch interests are focused on the use of catalysis for the “De Novo” asymmetric synthesis of biologically important natural products and carbohydrates. He and his group are interested in the application of these methodologies for SAR-type studies of natural and unnatural products with biomedical applications. His “De Novo” approach to carbohydrate chemistry was recognized in 1999 with the Arnold and Mabel Beckman Young Investigator award and in 2009 by the American Chemical Society’s Carbohydrate division with theHorace S. Isbell Award. He has authored over 150 manuscripts and reviews in the areas of organic synthesis, carbohydrates, medicinal chemistry and chemical biology.

讲座摘要：

The O’Doherty research group has been working in two related areas of organicsynthesis: carbohydrate synthesis and natural product synthesis. The unifying theme thatconnects our research in these two areas is our use of asymmetric catalysis. Fundamentalto our approach is the development of highly efficient routes that transform, via catalysis,inexpensive achiral starting materials into enantiopure products, which are poised for theconversion into complex molecules with biologically relevant properties (i.e.,enantioselective synthesis of a new“chiral pool”via asymmetric catalysis). The ultimategoal of these synthetic projects is to develop enantioselective routes to these complexbiologically active carbohydrates and natural products in sufficient quantities that areamenable for biomedical investigations. Our recent efforts to apply this methodology inmedicinal chemistry Structure Activity Relationship studies will be detailed (e.g.,SL0101 as RSK inhibitors, and Cardiac Glycosides as anti-cancer agents).

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